GSE30070

• A miRNA signature distinguishing gastric cancer from normal stomach epithelium was identified. 

• 30 miRNAs were significantly inversely correlated with TTP whereas 28 miRNAs were significantly positively correlated with TTP of
  82 cancer patients (P<0.05). 

• Prominent among the upregulated miRNAs associated with chemosensitivity were miRNAs known to regulate apoptosis, including let-7g, miR-342, miR-16, miR-181, miR-1, and miR-34. 

• When this 58-miRNA predictor was applied to a separate set of pre- and post-treatment tumor samples from the 8 clinical responders, all of the 8 pre-treatment samples were correctly predicted as low-risk, whereas samples from the post-treatment tumors that
  developed chemoresistance were predicted to be in the high-risk category by the 58 miRNA signature, suggesting that
  selection for the expression of these miRNAs occurred as chemoresistance arose.

• A classification model has been built using Trainset. The selected probes were:
  1. 1248-mir-148
  2. 10677-mir-17
  3. 11627-u6

• The model has been tested using Testset.