GSE56350

• The aim of the study was to identify a microRNA signature for metastatic CRC (colorectal cancer) that could predict and differentiate metastatic target organ localization.

• Hsa-miRNA-21, Hsa-miRNA-93, and Hsa-miRNA-103 upregulation together with hsa-miR-566 downregulation defined the CRC metastatic signature.

• This study provided the first microRNAs signature that could discriminate between colorectal recurrences to lymph nodes and liver
  and between colorectal liver metastasis and primary hepatic tumor.

• MicroRNAs signatures are highly tissue specific and can be used to classify cancers, and to identify the primary tumor of a metastatic lesion of unknown origin.

• A classification model ( metastasis tissue against primary tumor) has been built using Trainset. The selected probes were:
  1. hsa-mir-150
  2. hsa-mir-143
  3. hsa-mir-128a
  4. hsa-mir-122
  5. hsa-mir-345

• The model has been tested using Testset.